Margaret A. Goodell, Ph.D.

Hematology / Oncology
Center for Cell and Gene Therapy

Hematopoietic stem cell differentiation and proliferation

Margaret A. Goodell, Ph.D., received the award for her research on hematopoietic stem cell differentiation and proliferation. Dr. Goodell’s current research attempts to uncover the fundamental mechanisms that regulate stem cells in adults, with the ultimate goal of facilitating their use for cell and gene therapies. She is also attempting to harness adult stem cells for tissue and organ repair, using novel approaches involving cell fusion.

Dr. Goodell’s nomination was based on the following publications:

McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA." Muscle-derived hematopoietic stem cells are hematopoietic in origin. ". Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1341-6.

Camargo FD, Green R, Capetanaki Y, Jackson KA, Goodell MA, Capetenaki Y. " Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates.".Nat Med. 2003 Dec;9(12):1520-7. Epub 2003 Nov 16.

Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA. " Molecular signatures of proliferation and quiescence in hematopoietic stem cells. ". PLoS Biol. 2004 Oct;2(10):e301.