Rationale for IMPPHR

  • Variceal hemorrhage in children is a feared major complication of portal hypertension and is associated with risk of morbidity and mortality.
  • Optimal approaches to the management of variceal hemorrhage remain controversial and informed by limited high quality data
  • IMPPHR was developed to inform clinical decision-making in the management of children with portal hypertension.
  • The following are the major areas of investigation for which data collection occurs in IMPPHR
    • mortality of 1st variceal hemorrhage
    • “feasibility and efficacy” of primary prophylaxis of variceal hemorrhage
    • approach to secondary prophylaxis of variceal hemorrhage
  1. Morbidity and Mortality of First Variceal Hemorrhage - Jean Molleston
  2. Experiences in Endoscopic Primary Prophylaxis in Children - Mathieu Duche
  3. Rationale for Primary Prophylaxis in Adults - Roberto de Franchis
  4. Complexities of Clinical Trials in Pediatrics - Simon Ling
  5. International Registries in Pediatric Liver Diseases, The PSC Experience - Mark Deneau